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Adrenal insufficiency treatment5/20/2023 ![]() Rarely, CPA can produce blood clots, liver damage, excessively high prolactin levels, prolactinomas, and meningiomas. Īt very high doses in aged men with prostate cancer, CPA can cause cardiovascular side effects. Pooled tolerability data for CPA is not available in the literature. Few quantitative data are available on many of the potential side effects of CPA. Some of the side effects of CPA can be improved or fully prevented if it is combined with an estrogen to prevent estrogen deficiency. ![]() Weight gain can occur with CPA when it is used at high doses. ![]() Side effects of CPA include hypogonadism and associated symptoms such as demasculinization, sexual dysfunction, infertility, and osteoporosis breast changes such as breast tenderness, enlargement, and gynecomastia emotional changes such as fatigue and depression and other side effects such as vitamin B12 deficiency, weak glucocorticoid effects, and elevated liver enzymes. It is generally well- tolerated and has a mild side-effect profile, regardless of dosage, when it used as a progestin or antiandrogen in combination with an estrogen such as ethinylestradiol or estradiol valerate in women. ![]() The side effects of cyproterone acetate ( CPA), a steroidal antiandrogen and progestin, including its frequent and rare side effects, have been studied and characterized.
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